5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme implicated in obesity, metabolic dysfunction, and aging. Chemical Formula: C₁₀H₁₁N₂⁺ Molecular Weight: 159.21 g/mol CAS Number: 42464-96-0 Classification: Small molecule NNMT inhibitor NNMT catalyzes the methylation of nicotinamide (vitamin B3) to 1-methylnicotinamide (1-MNA), consuming S-adenosylmethionine (SAM) as a methyl donor. High NNMT activity depletes NAD+ and SAM, impairing cellular energy metabolism. 5-Amino-1MQ selectively inhibits NNMT (IC₅₀ = 1.2 μM), preventing nicotinamide degradation and preserving NAD+ availability. By blocking NNMT, 5-Amino-1MQ increases intracellular NAD+ levels: - Mitochondrial energy production (electron transport chain) - Sirtuin activation (longevity pathways, DNA repair) - Cellular metabolism and redox balance - Increases SAM availability for methylation-dependent processes - Reduces lipoge
5-Amino-1MQ: NNMT Inhibitor Research Guide
Comprehensive overview of 5-Amino-1MQ, a selective NNMT inhibitor studied for metabolic regulation, obesity research, and muscle regeneration applications.