Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide, PNB-0408) is a synthetic oligopeptide derived from angiotensin IV, engineered by researchers at Washington State University for cognitive enhancement and neuroprotection research. Chemical Name: N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide Molecular Formula: C₂₇H₄₄N₄O₅ Molecular Weight: 504.28 Da Classification: Synthetic dipeptide derivative, nootropic agent - N-terminal: Hexanoic acid attached to tyrosine (increases lipophilicity) - C-terminal: Isoleucine linked to 6-aminohexanoic acid (protects against peptidases) - Core structure: Tyr-Ile dipeptide backbone These modifications enable blood-brain barrier penetration and oral bioavailability. Dihexa's procognitive effects stem from the hepatocyte growth factor (HGF) / c-Met receptor system: 1. High-affinity HGF binding (Kd ≈ 65 pM) 2. c-Met phosphorylation in presence of subthreshold HGF 3. Downstream activation: - PI3K/AKT pathway → neuronal survival - Synaptic plas
Dihexa: Cognitive Enhancement Peptide Research Guide
Comprehensive overview of Dihexa (PNB-0408), an angiotensin IV-derived peptide studied for its potent procognitive and synaptogenic effects through HGF/c-Met pathway activation.