Epithalon (also Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG), developed from pineal gland extract research. It has become one of the most studied anti-aging peptides. Molecular Formula: C₁₄H₂₂N₄O₉ Molecular Weight: 390.35 Da A 2003 study demonstrated that Epithalon reactivates telomerase in telomerase-negative human fetal fibroblasts, leading to: - Approximately 33% telomere elongation - Extended cell proliferation beyond the Hayflick limit - Upregulation of hTERT (human telomerase reverse transcriptase) - Telomeres are protective DNA caps (TTAGGG repeats) at chromosome ends - They shorten with each cell division, leading to cellular senescence - Telomerase is normally silenced in adult somatic cells but active in stem cells Molecular studies show Epithalon: - Preferentially binds H1.3 and H1.6 histones - Remodels chromatin structure to restore "youthful" gene expression patterns - Activates ribosomal genes and neuronal differentiation mar
Epithalon: Telomerase Activation Research Guide
A comprehensive guide to Epithalon, the synthetic tetrapeptide studied for telomerase activation and longevity mechanisms.