IGF-1 LR3 (Insulin-Like Growth Factor-1 Long Arginine 3) is a synthetic modified analog of natural IGF-1 with enhanced properties for research applications. Composition: 83 amino acids (9.1 kDa molecular weight) Key Modifications: - 13 additional amino acids added to N-terminal - Arginine substitution at position 3 (replacing glutamic acid) - These changes prevent binding to IGF-binding proteins (IGFBPs) Extended Half-Life: 20-30 hours (vs. minutes for natural IGF-1) — remains active up to 120× longer than standard IGF-1. - PI3K/Akt/mTOR signaling: Drives protein synthesis and growth - MAPK pathway: Influences cell proliferation and differentiation - Satellite cell activation: Muscle stem cells for repair and new fiber creation Research shows IGF-1 LR3 may affect both: 1. Hyperplasia: Creation of new muscle cells 2. Hypertrophy: Increased size of existing muscle fibers 3. Mitogenesis: Development of new muscle fibers | Area | Observed Effects | |------|------------------|
IGF-1 LR3: Extended Growth Factor Research Guide
Understanding IGF-1 LR3, the modified insulin-like growth factor with extended half-life for muscle research.