SLU-PP-332 is a first-in-class, small-molecule agonist of the estrogen-related receptors (ERRα, ERRβ, and ERRγ). It is being studied for its potent ability to mimic the metabolic and physiological effects of endurance exercise. Chemical Class: Small molecule ERR pan-agonist Primary Targets: ERRα, ERRβ, ERRγ Classification: Exercise mimetic compound Research Status: Preclinical investigation Estrogen-Related Receptors (ERRs) are orphan nuclear receptors that regulate genes involved in: - Mitochondrial biogenesis - Oxidative metabolism - Cellular energy production Unlike estrogen receptors, ERRs do not bind estrogen but share structural similarities. SLU-PP-332 directly binds and activates all three ERR subtypes. By activating ERR signaling, SLU-PP-332 induces a metabolic state similar to physical exercise: | Effect | Mechanism | |--------|-----------| | Increased Mitochondrial Mass | Upregulates PGC-1α and mitochondrial genes | | Enhanced Fatty Acid Oxidation | Promotes lipid
SLU-PP-332: ERR Agonist Research Guide
Comprehensive overview of SLU-PP-332, a first-in-class ERR agonist studied for its ability to mimic the metabolic and physical benefits of endurance exercise.