> Educational Content Only: This compound is discussed for educational purposes only and is not currently offered by our company. Thymosin Alpha-1 (Tα1) is a 28-amino acid peptide originally isolated from thymic tissue. First characterized by Dr. Allan Goldstein in the 1970s, this naturally occurring peptide plays a crucial role in T-cell development and immune system regulation. It has become an important research tool for studying immune modulation mechanisms. - Molecular Weight: 3,108 Da - Amino Acid Sequence: Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH - Isoelectric Point: 4.2 (acidic peptide) - Solubility: Water-soluble - N-terminal: Acetylated serine Thymosin Alpha-1 exerts immunomodulatory effects through multiple pathways: - TLR Signaling: Activates Toll-like receptor 9 (TLR9) on dendritic cells - T-Cell Maturation: Promotes differentiation of T-cell precursors - Cytokine Modulation: Influences IL-2, IFN-α, and IFN-γ production - NK Cell Activation: Enhances natural killer cell activity 1. Increases CD4+ and CD8+ T-cell populations 2. Restores T-cell function in immunocompromised states 3. Promotes dendritic cell maturation 4. Modulates regulatory T-cell populations Research has investigated Thymosin Alpha-1 in: - Immune reconstitution models - T-cell development studies - Dendritic cell biology - Cytokine network regulation Areas of investigation include: - Viral hepatitis models - Immune response to viral infections - Bacterial sepsis studies - Immunocompromised host responses Studies have explored: - Immune checkpoint interactions - Tumor microenvironment modulation - Combination with immunotherapy approaches - Cancer vaccine adjuvant potential | Study Area | Key Finding | |------------|-------------| | T-Cell Biology | Promotes thymocyte differentiation to mature T-cells | | Dendritic Cells | Activates DC maturation via TLR9 pathway | | Cytokine Production | Enhances Type I interferon responses | | NK Cells | Increases NK cell cytotoxicity against target cells | Thymosin Alpha-1 has been: - Approved in some countries for hepatitis B treatment - Studied as an immune adjuvant - Investigated in combination therapy protocols - Evaluated for immune reconstitution applications For research applications: - Store lyophilized peptide at -20°C - Reconstitute with sterile water or saline - Avoid repeated freeze-thaw cycles - Use within designated timeframes after reconstitution - Protect from light and oxidation 1. Goldstein AL, et al. (1977). Thymosin alpha1: isolation and sequence analysis. PNAS. 2. Romani L, et al. (2007). Thymosin alpha1 activates dendritic cells. Blood. 3. Garaci E, et al. (2012). Thymosin alpha1: from bench to bedside. Ann NY Acad Sci. 4. King R, Tuthill C. (2016). Immune modulation with thymosin alpha1 treatment. Vitamins and Hormones. --- This compound is discussed for educational purposes only and is not currently offered by our company.
Thymosin Alpha-1: Immune Modulation Research Guide
Explore Thymosin Alpha-1, a thymic peptide with immunomodulatory properties. Learn about its mechanism of action, research applications in immune function studies, and key scientific findings.