> Educational Content Only: This compound is discussed for educational purposes only and is not currently offered by our company. Thymulin, also known as Facteur Thymique Sérique (FTS) or serum thymic factor, is a nonapeptide hormone produced exclusively by thymic epithelial cells. Discovered in the 1970s, thymulin is unique among thymic peptides in its absolute requirement for zinc to achieve biological activity, making it a fascinating subject for research at the intersection of immunology and trace element biology. - Molecular Weight: 857 Da (zinc-bound form) - Amino Acid Sequence: Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn (pyroGlu-AKSQGGSN) - Zinc Binding: Essential for biological activity - N-terminal: Pyroglutamic acid (cyclized glutamate) - Zinc Coordination: Involves Lys3, Ser4, and Asn9 residues - Zinc Requirement: Inactive without zinc; 1:1 molar ratio required - Conformational Change: Zinc binding induces bioactive conformation - Zinc Status Biomarker: Thymulin activity
Thymulin: Thymic Hormone Research Guide
Comprehensive overview of Thymulin, a zinc-dependent thymic hormone essential for T-cell maturation. Explore its mechanism of action, research applications in immunology and aging studies.